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Feb 2019;7(1):3-12
"One theory behind this side effect is that Ozempic can affect the levels of certain hormones in the body, including glucagon-like peptide-1 (GLP-1)," Purdy explained
Elevated blood glucose or insulin levels significantly blunt the GH response
The concern for precipitating renal injury led to the 2024 Kidney Disease: Improving Global Outcomes (KDIGO) guideline recommendation to consider holding renin-angiotensin-aldosterone system inhibitors in the 48 to 72 hours before elective surgery in patients with chronic kidney disease, while recognizing the risk of delayed resumption of therapy
Clinical studies have shown that it is highly effective for weight loss
This study showed that the risk of recurrent pancreatitis in a cohort of patients taking GLP-1 receptor agonists (10%) was likely no greater than what is observed in the general population and that more than half of the episodes of recurrent pancreatitis were attributable to causes other than GLP-1 receptor agonist therapy
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